Approach

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Our platform uses an advanced suite of cutting-edge biology, engineering and technology to identify proprietary therapeutic candidates with greater precision at an early stage of development, thereby increasing the probability of success of delivering better optimized therapeutics to patients.

01

Patient Derived Neuronal Models

Our stem cell technologies enable us to generate disease-relevant human cellular models, and our CRISPR engineering provides the capability to customize these models. 
Advanced culture methods based on proprietary know-how yield uniform preparations of human neurons. These cells are produced at ultra large scale with a strong degree of consistency and reproducibility across cell lines for utility in high-throughput drug screening.

02

Determinative Measurements

Our proprietary optogenetic electrophysiology engineering and software allows uniquely fast and sensitive measurements of neuronal activity with massive data capture. 
These noninvasive methods capture approximately 500 data points per cell at a throughput of 24,000 cells per hour, yielding precise, parallel readouts of action potentials with single-cell resolution. Datasets can amass up to 4 terabytes per day. 

03

AI & Machine Learning

Our computational analytics decipher the mass amounts of collected data to discover key disease phenotypes and therapeutic candidates that correct them. 
Machine learning and statistical tools identify how a disease impacts neuronal behavior, and automated algorithms enable high-throughput screening and quantification of therapeutic attributes across different modalities.